Alumis, established in 2005, is a leading innovator in sustainable energy solutions. The company's cutting-edge technologies in solar power and energy storage have revolutionized the renewable energy sector, driving the transition towards a cleaner and more efficient future. Alumis continues to push boundaries with its comprehensive range of eco-friendly products and services, making significant strides in combating climate change and promoting environmental sustainability on a global scale.

alumis

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;The Data Systems &amp; Clinical Programming Specialist (Contractor) will be responsible to support Data Management (DM) as part of the Clinical Programming function in a rapidly evolving environment, in accordance with industry standards. This role will support Data Systems and Clinical Programming activities and deliverables across programs as directed by the Director and Associate Director, DS&amp;CP. Essential Responsibilities: Support development and production operation activities within the Data Systems and Clinical Programming function Maintain Smartsheet trackers for report requests, Production reports, and other DS&amp;CP operational documentation Participate in the development of report specifications for SAS Clinical Programming reports, and other custom reports/outputs as needed Review programmed reports/outputs for accuracy against requirements and provided specifications Provide/transfer source files for reports and dashboards and ensure automated transfers have completed successfully Transfer programmed reports/outputs to appropriate locations for cross-functional team use Support requests for new/updated Automated Transfer Service (ATS) vendors and jobs and investigate issues or trigger jobs manually as needed Provide user access for DM tools Support Alumis’ standard CRFs and standard edit checks initiatives Participate in EDC, IRT, and eCOA User Acceptance Testing (UAT) Ensure DS&amp;CP study-specific documentation is in an inspection-ready Support DS&amp;CP in cross-functional meetings, as applicable Ensure DS&amp;CP project deliverables are completed on time and in accordance with quality standards and regulatory requirements Ensure compliance with all relevant data privacy regulations and maintain the security of clinical trial data Qualifications: 5+ years of relevant experience and has earned a BS or equivalent degree 2+ years of experience with clinical trials and data management Understanding of the programming development life cycle Knowledge and experience in EDC Experience with SAS, SQL, and/or other clinical programming tools Experience working and effectively communicating with global programming teams preferred Experience with CDISC standards (CDASH, SDTM) preferred Strong interpersonal, organizational, and communication (oral and written) skills Logical thinking, attention to detail and accuracy, strong organizational skills, and problem-solving abilities Ability to prioritize and to adapt quickly to changing business conditions with a “can-do” attitude

Data Systems & Clinical Programming Specialist (Contractor)

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp; &nbsp; We are seeking an experienced Regional Director of Medical Science Liaisons (MSLs) with expertise in medical dermatology. The successful candidate will be responsible for leading and overseeing MSLs, ensuring the effective dissemination of scientific and clinical information, building relationships with key opinion leaders (KOLs), and supporting the strategic goals of the Medical Affairs organization. This role will require a deep understanding of medical science, excellent leadership capabilities, and a strong ability to drive the success of cross-functional teams. We will be seeking one individual for the Western US and one for the Eastern US. &nbsp; Responsibilities: Field-based Leadership of Regional DPEGs and IDNs Serve as primary point of contact with the clinical leaders, educational leaders, and C-suite executives of Dermatology Private Equity-backed Groups, DPEGs, to build trusting professional relationships Develop deep understanding of DPEG structures, performance metrics, and educational needs Develop cross-functional engagement strategy to build the groundwork for launch Co-create data-driven value proposition to improve patient outcomes Leadership &amp; Team Management: Lead, mentor, and manage a team of MSLs, fostering a collaborative, high-performing, and scientifically rigorous culture. Provide guidance on the development and execution of territory plans, objectives, and key performance indicators (KPIs) for each MSL. Conduct regular performance evaluations, identify skill gaps, and support MSL development through coaching, training, and career growth opportunities. Collaborate with the Medical Affairs leadership team to align MSL activities with organizational priorities and strategic initiatives. Strategic Planning &amp; Execution: Contribute to the development of MSL tactics in line with corporate and therapeutic area goals. Drive the execution of MSL tactics within assigned region. Ensure MSLs are equipped with the latest scientific data and clinical information, and support their integration into both regional and national-level initiatives. Scientific Exchange &amp; KOL Relationship Management: Cultivate strong, long-lasting relationships with KOLs, healthcare providers, academic researchers, and key stakeholders through active field engagement in the region. Serve as a scientific resource and point of contact for KOLs to address inquiries regarding the company’s pipeline, products, and scientific advancements. Represent the company at scientific congresses, advisory boards, and other relevant forums to enhance scientific and therapeutic understanding. Cross-Functional Collaboration: Provide strategic input into the development of clinical trials, publication plans, and other medical activities by leveraging field insights and customer feedback. Collaborate with the Medical Affairs leadership to ensure appropriate deployment of MSL resources to support clinical, regulatory, and commercial objectives. Compliance &amp; Reporting: Ensure all MSL activities are conducted in compliance with regulatory, ethical, and company standards, including GxP (Good Clinical Practice) and HIPAA regulations. Provide regular updates to MA management on team progress, KOL engagement, and other key initiatives, including metrics on impact and outcomes. Stay abreast of the competitive landscape and emerging trends in dermatology, rheumatology, and neurology, ensuring MSL activities reflect the latest scientific advancements. &nbsp; Qualifications: Education: o PhD, PharmD, MD, or other advanced degree in a relevant scientific discipline (e.g., Biology, Pharmacology, Medicine). Experience: o Minimum of 10 years of experience in Medical Affairs or related scientific roles, with leadership experience in managing a team of MSLs or scientific professionals. o In-depth knowledge of medical dermatology, including clinical practice, research, and evolving treatment paradigms. o Proven track record of successful relationship-building with KOLs, HCPs, and key stakeholders within the medical community. o Experience working in cross-functional teams, with a demonstrated ability to collaborate effectively with commercial, clinical, regulatory, and other business functions. Skills &amp; Competencies: o Excellent leadership and team management skills, with the ability to inspire and develop a high-performing team. o Strong communication, presentation, and interpersonal skills, with the ability to engage effectively with internal and external stakeholders. o Deep understanding of the pharmaceutical industry, including regulatory and compliance requirements, scientific data dissemination, and product lifecycle management. o Ability to translate complex scientific information into actionable insights for diverse audiences, including KOLs, healthcare professionals, and internal teams. o Strong problem-solving, strategic thinking, and decision-making skills. Travel: o Willingness to travel extensively (50-75%) as required for KOL engagement, scientific meetings, and team management activities. Preferred Qualifications: · Experience in therapeutic areas of medical dermatology. · Previous experience working in a leadership role within a biopharmaceutical company or a global pharmaceutical organization. · Familiarity with clinical trial processes, publication planning, and scientific communication in a corporate environment. The salary range for this position is $220,00 to 250,000 USD annually. This salary range is an estimate, and the actual salary may very based on the Company’s compensation practices degree and background. &nbsp; This position is primarily remote with travel. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way.

Regional Director of MSLs

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Director, GCP Compliance&nbsp; Alumis Inc is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer – our goal is to fundamentally change the outcomes for these patients. Reporting to the Executive Director, GCP Compliance, the Director of GCP Compliance serves as a strategic leader responsible for GCP oversight, Inspection Readiness (IR), and cross-functional quality partnership. This role provides GCP Compliance direction for clinical programs, advances clinical process excellence, and ensures development programs operate with the highest standards of quality, compliance, and inspection readiness. Strategic Priorities Lead Inspection Readiness (IR) strategy and execution across assigned clinical programs, ensuring teams are prepared for regulatory engagement. Serve as a strategic partner to QA, collaborating on compliance risk mitigation, quality signals, and inspection readiness activities. Provide strategic oversight for issue management across clinical programs, ensuring GCP issues are identified, assessed, escalated, and resolved with urgency and transparency. Drive the development and reporting of compliance metrics, dashboards, and tools that enable clear, data‑driven quality decisions. Champion a culture of quality and compliance within Development, serving as a visible advocate in partnership with QA. Operational Responsibilities Lead GCP training initiatives, including development and delivery, ensuring content is current, impactful, and aligned with organizational growth. Support the evolution of Clinical Study Management processes to align with regulatory expectations and operational excellence. Partner with Development Operations, Biometrics, Pharmacovigilance, QA, and Regulatory Affairs to proactively identify and mitigate compliance risks. Develop and deliver GCP training programs for internal teams and external partners to champion a quality-first mindset, reinforcing consistent compliance behaviors. Support initiatives that reinforce strong procedural compliance across clinical programs Collaborate with QA on deviation management, CAPAs and audit/inspection finding resolution and close out. The Ideal Candidate Holds an advanced degree in Life Sciences, Pharmacy, or related field is preferred. Brings 10+ years of experience in GCP quality/compliance, including 3+ years in a leadership role. Possesses deep knowledge of ICH-GCP, FDA, EMA, and other global regulatory requirements. Demonstrates proven success supporting or leading inspection readiness and serving as an interface with global health authorities during inspections. Communicates with clarity, leads with influence, and builds trust across teams. Experience in biotech or pharmaceutical industry, ideally in late-stage clinical development. Combines strategic insight with strong operational execution, translating executive direction into clear, actionable initiatives. Acts with high integrity and commitment to ethical research practices; able to navigate complex regulatory and organizational environments. Leads with collaboration and agility, fostering strong relationships and effective decision‑making across the organization. This position is located in South San Francisco, CA, with an expectation to be on-site Tuesday through Thursday. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; &nbsp; The salary range for this position is $200,500 USD to $240,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. &nbsp;&nbsp; This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday.&nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way. &nbsp; &nbsp;

Director, GCP Compliance

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis is seeking a Director of Clinical Pharmacology &amp; DMPK to drive clinical pharmacology strategy and PK/PD modeling for our small-molecule programs in immune-mediated diseases. This role partners closely with cross-functional teams and reports to the Head of Clinical Pharmacology &amp; DMPK. Specific responsibilities include but are not limited to:&nbsp; &nbsp; Lead clinical pharmacology strategy, dose selection, and PK/PD and biomarker planning across early and late-stage programs. Conduct and interpret PK, PK/PD, exposure–response, and simulation analyses using tools such as NONMEM, WinNonlin, R, Python, and Simcyp. Integrate translational and nonclinical PK/PD data to support FIH dose projections and DDI assessments. Oversee bioanalytical CROs, ensuring high-quality PK/PD/biomarker data and GLP/GCP compliance. Partner with Clinical Operations on sample management and protocol design. Communicate quantitative findings clearly and contribute to regulatory documents (protocols, IBs, INDs, NDAs, IMPDs). Collaborate across Clinical Development, Biostats/Data Science, Nonclinical, and Program Management. Key Requirements and Qualifications&nbsp; PhD, PharmD, or equivalent in Pharmacokinetics, Pharmacology, or related field. 6 to 8+ years of industry experience in Clinical Pharmacology, DMPK, or Quantitative Pharmacology. Strong expertise in PK, PK/PD, DMPK, and translational sciences. Proficiency with modeling/simulation platforms (NONMEM, WinNonlin, Simcyp, R, Python). Excellent communication, organization, and ability to work independently in a fast-paced environment. Alumis Inc. is an equal opportunity employer. The salary range for this position is $200,000 USD to $240,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. &nbsp;&nbsp; This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday.&nbsp; Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way. &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;

Director Clinical Pharmacology & DMPK

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;The Data Management (DM) Contractor will be responsible for ensuring high-quality management of clinical trial data in a rapidly evolving environment, in accordance with industry standards. The DM Contractor will support and/or lead DM activities and deliverables across one or multiple studies. Essential Responsibilities: May serve as DM Study Lead or DM support for one or more studies Represent DM in cross-functional meetings as applicable Ensure DM project deliverables are completed on time and in accordance with quality standards and regulatory requirements from study start-up through study closure/archival Apply effective vendor management throughout the study Responsible for ensuring complete and accurate DM documentation such as eCRF specifications, eCRF completion guidelines, annotated CRFs, data validation specifications, data transfer agreements and data management plans Perform thorough development testing of the eCRF prior to deployment, inclusive of creating User Acceptance Test (UAT) Plans, Test Scripts and executing testing as applicable Ensure accurate development and execution of data integrations between EDC, IXRS and/or external vendor data sources Responsible for setup and management of data transfers for assigned studies, including review of test data transfers for consistency with data transfer agreements Participate in study document reviews, e.g. clinical study protocols, statistical analysis plans, Mock Tables, Figures and Listings (TFL) shells Perform supplemental data reviews according to the data quality checks outlined in the data validation specifications or Clinical Data Review Plan (CDRP) Participate in reviews of blinded TFL output prior to final database locks Report query trends and data/query/SDV metrics to the Study Execution Team (SET) Participate in the development of EDC custom report specifications, SAS Clinical Programming report specifications and/or associated outputs as needed Ensure DM project documentation is in an inspection-ready state Qualifications: 10+ years of relevant experience and has earned a BS or equivalent degree; MS or MBA a plus Experience running Ph I-IV clinical trials, both in-house and through CRO partners Strong knowledge and experience in EDC and other key technologies (e.g., IXRS, data visualization)&nbsp; Proficiency in CDISC standards (CDASH, SDTM, ADaM) Experience with SAS, SQL and/or other clinical programming tools Proficiency in clinical research regulations and guidance, including FDA CFR and ICH GCP&nbsp; Depth of experience across all aspects of DM, including but not limited to: CRF and database development, data quality assurance and analytics, data transfer management, vendor management, DM study documentation and inspection readiness.&nbsp; Strong understanding&nbsp;of the application of MedDRA and WHO Drug clinical data coding classification systems Strong interpersonal, organizational, and communication (oral and written) skills Demonstrated ability to cultivate strong working relationships with internal and external colleagues. Logical thinking, attention to detail and accuracy, strong organizational skills, and problem-solving abilities Ability to prioritize and to adapt quickly to changing business conditions with a “can-do” attitude Capable of proactively identifying project challenges and risks and proposing appropriate and strategic solutions to issues. Alumis Values&nbsp;• We Elevate• We Challenge• We Nurture This position is located in South San Francisco, CA and contractors are expected to be onsite Tuesday-Thursday. Open to remote applicants with requirement to be onsite 1-2x a quarter.

Data Management Contractor

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;The Director, Data Systems (DS) and Clinical Programming (CP) will be responsible for leading and managing the Clinical Programming function within Data Management (DM). This position will report to the VP, Data Management and Clinical Programming. Responsibilities:&nbsp; Lead and manage the Data Systems and Clinical Programming function within DM Drive the implementation of various technology solutions to augment existing DM processes, optimize efficiency and enhance overall data quality assurance Lead and/or participate in AI-related initiatives for DM Develop and implement strategies for optimizing data flow, database builds, and integration of external technologies. Oversee the validation of the EDC platform, ensuring ongoing system optimization. Manage relationships with key external vendors, ensuring alignment with organizational goals. Ensure compliance with all relevant data privacy regulations and maintain the security of clinical trial data. Ensure DS&amp;CP project deliverables are completed on time and in accordance with quality standards and regulatory requirements. Collaborate with other departments to align data strategy with broader organizational goals and objectives. Mentor and develop team members, fostering a culture of continuous learning and growth within the team. Oversee all SAS clinical programming requests and standardize the clinical programming specification development process. Develop and/or maintain Alumis’ standard CRFs and standard edit checks, inclusive of indication-specific standards. Develop DS&amp;CP SOPs and Work Instructions. Lead the development and/or maintenance of standard vendor Data Transfer Agreements (DTAs). Oversee the development and execution of technical initiatives within DM, including the implementation of key data visualizations and dashboards for DM, such as Clean Patient Tracking, data currency, and rolling batch freeze progress. Integrate the usage of data analytics within DM to further optimize current processes. Provide strategic oversight of high-priority projects, including database builds, user access management, and the release of system updates. Participate in EDC, IRT and eCOA User Acceptance Testing (UAT) Ensure accurate development and execution of data integrations between EDC, IXRS or additional external vendor data sources Ensure DS&amp;CP study-specific documentation is in an inspection-ready state and represent the DS&amp;CP function in inspections as applicable. Represent DS&amp;CP in cross-functional meetings as applicable Act as a key stakeholder in developing and executing strategies to accelerate drug development through innovative data management practices. Qualifications:&nbsp; 12+ years of relevant experience and has earned a BS or equivalent degree; MS or MBA a plus Experience supporting Ph I-IV clinical trials, both in-house and through CRO partners Strong knowledge and experience in EDC and other key technologies (e.g., IXRS, data visualization)&nbsp; Proficiency in CDISC standards (CDASH, SDTM, ADaM) Experience with SAS, SQL and/or other clinical programming tools Proficiency in clinical research regulations and guidance, including FDA CFR and ICH GCP&nbsp; Depth of experience across all aspects of DM, including but not limited to: CRF and database development, data quality assurance and analytics, data transfer management, vendor management, DM study documentation and inspection readiness.&nbsp; Strong understanding&nbsp;of the application of MedDRA and WHO Drug clinical data coding classification systems Strong interpersonal, organizational, and communication (oral and written) skills Demonstrated ability to cultivate strong working relationships with internal and external colleagues. Logical thinking, attention to detail and accuracy, strong organizational skills, and problem-solving abilities Ability to prioritize and to adapt quickly to changing business conditions with a “can-do” attitude Capable of proactively identifying project challenges and risks and proposing appropriate and strategic solutions to issues. Willing to travel if required &nbsp; Alumis Values&nbsp;• We Elevate&nbsp;• We Challenge&nbsp;• We Nurture&nbsp; This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday. Open to remote applicants with requirement to be onsite 1-2x a quarter. The salary range for this position is $200,000 USD to $225,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. Alumis Inc. is an equal opportunity employer. &nbsp; &nbsp;

Director, Data Systems and Clinical Programming

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;We are seeking an experienced Senior Manager, FP&amp;A – Research &amp; Technical Operations to join our team in a fast-paced, high-growth environment. This position will serve as a strategic finance business partner to the Research and Technical Operations organizations, supporting a growing portfolio of programs and operational priorities. In this role, you will play a critical part in driving planning and forecasting processes, delivering decision support for functional leadership, and assisting the Sr. Director of FP&amp;A in overall planning strategy and execution. This position will also involve close interaction with the Accounting team during month-end close processes. Responsibilities Partner closely with Research and Technical Operations teams to provide effective planning, forecasting, and analysis; provide senior leadership and business partners with appropriate tools and insights to set goals and measure performance. Attend cross-functional program and functional leadership meetings; proactively identify risks, opportunities, and tradeoffs and translate them into clear financial implications. Partner with Technical Operations and Accounting to support COGS and gross margin planning/forecasting and related performance analysis. Support Technical Operations’ operating models by validating key assumptions, running scenarios, and communicating financial implications to functional leaders. Own financial reporting for supported functions, including monthly comparison of actual vs. budget/forecast results and relevant variance analysis, in a timely and accurate manner. Collaborate with the Accounting team on monthly close to ensure accruals and expenses are recorded accurately and promptly. Assist Sr. Director, FP&amp;A in the management of the LRP and budget processes, support compliance of internal controls, preparation of finance materials for the Board, and other high priority projects. Collaborate, influence, and build credibility with business partners across the organization, especially within Research and Technical Operations. Educate program and functional leaders about the budgeting/forecasting process and the importance of their role in a successful process. Qualifications Bachelor’s in Finance, Accounting or relevant degree. 7+ years of progressive financial reporting, planning and analysis experience in the pharmaceutical or biotechnology industry. Prior experience supporting Research/R&amp;D and/or Technical Operations organizations is highly preferred. Experience supporting manufacturing/CMC/supply chain finance and partnering through commercialization or launch-readiness activities is a plus. System savvy, ideally with experience implementing or overseeing financial planning and reporting tools. Experience with Adaptive Insights is a plus. Strong and advanced Excel modeling and analytical skills as well as solid accounting knowledge. Strong written, verbal, and interpersonal skills. Alumis Values&nbsp;• We Elevate&nbsp;• We Challenge&nbsp;• We Nurture&nbsp; This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday.&nbsp; The salary range for this position is $165,000 USD to $200,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. Alumis Inc. is an equal opportunity employer.

Senior Manager, FP&A - Research & Technical Operations

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp; &nbsp; Position Summary Alumis is seeking an experienced Executive Medical Director or Senior Medical Director to lead clinical development strategy and execution for Phase 1 and Phase 2 studies evaluating envudeucitinib and A-005 across new indications identified for expansion of the Alumis pipeline. This high-impact role will be instrumental in shaping the company's clinical development portfolio, from indication selection through proof-of-concept studies, and will serve as a key scientific leader interfacing with internal teams, regulatory authorities, and the external medical community. --- Key Responsibilities Clinical Development Strategy &amp; Leadership · Lead the design, planning, and execution of Phase 1 and Phase 2 clinical studies for A-005 and additional pipeline molecules in new therapeutic indications · Develop and refine clinical development plans, including study synopses, protocols, and integrated development strategies for new indications · Provide clinical and scientific leadership to cross-functional study teams, ensuring alignment on program goals, timelines, and deliverables · Collaborate with Translational Medicine and Research teams to evaluate and prioritize new indication opportunities based on scientific rationale, competitive landscape, and unmet medical need Study Execution &amp; Oversight · Serve as the Medical Monitor for assigned Phase 1 and 2 studies, ensuring patient safety and scientific integrity · Oversee medical aspects of study conduct, including safety surveillance, protocol amendments, and data review · Partner with Clinical Operations, Biostatistics, and Regulatory Affairs to ensure efficient study execution and high-quality data generation · Lead interactions with Data Safety Monitoring Boards (DSMBs) and provide medical input for safety analyses Regulatory &amp; External Engagement · Contribute to regulatory strategy and serve as a clinical representative in interactions with FDA and international regulatory authorities (EMA, PMDA, etc.) · Prepare and review clinical sections of regulatory submissions, including IND amendments, briefing documents, and meeting packages · Represent Alumis at scientific conferences, advisory boards, and with Key Opinion Leaders (KOLs) to advance clinical programs and gather external insights · Build and maintain relationships with investigators, academic collaborators, and the broader medical community Cross-Functional Collaboration · Work closely with Translational Sciences, Biomarker, and Pharmacology teams to integrate biomarker strategies into clinical study designs · Collaborate with Commercial and Medical Affairs teams on disease landscape assessments and indication prioritization · Provide clinical expertise to support business development activities, including evaluation of potential partnerships or in-licensing opportunities Team Development · Mentor and develop junior medical staff, fostering a culture of scientific excellence and collaboration · Contribute to building Alumis's clinical development capabilities as the organization grows --- Required Qualifications · MD required; board certification or fellowship training in Rheumatology, Dermatology, or a related specialty strongly preferred · 10+ years of pharmaceutical/biotechnology industry experience in clinical development, with a significant focus on immunology or autoimmune diseases · Demonstrated experience leading Phase 1 and Phase 2 clinical studies from design through data readout · Track record of successful regulatory interactions (FDA, EMA) and experience preparing IND/CTA submissions · Deep understanding of early clinical development, including dose-finding strategies, biomarker integration, and adaptive trial designs · Strong scientific acumen with the ability to critically evaluate preclinical and clinical data to inform development strategy · Experience with JAK/TYK2 inhibitors or related immunomodulatory mechanisms preferred · Excellent leadership, communication, and interpersonal skills with the ability to influence cross-functional teams in a matrixed environment · Strategic mindset with demonstrated ability to balance scientific rigor with business objectives --- Preferred Qualifications · Experience with indication expansion or lifecycle management for immunology assets · Prior experience at a small or mid-sized biotechnology company; comfort operating in a fast-paced, resource-conscious environment · Established relationships with KOLs in rheumatology, dermatology, or gastroenterology · Experience with multiple autoimmune indications (e.g., psoriasis, psoriatic arthritis, lupus, atopic dermatitis, CNS inflammatory and degenerative diseases) · Familiarity with regulatory pathways for expedited development (Breakthrough Therapy, Fast Track) --- Travel Requirements Travel required (approximately 20-30%) to support investigator meetings, scientific conferences, regulatory interactions, and site visits. --- &nbsp; The salary range for this position is $300,000 USD to $400,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday. Remote candidates will be considered on a case-by-case basis. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way.

Senior/Executive Medical Director, Clinical Development (New Indications)

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis is seeking a high-impact Senior Director to help shape and deliver U.S. market access strategy for a late-stage immunology asset in dermatology. Reporting to the SVP of Market Access, this role is designed for someone who thrives in a lean environment, takes ownership beyond their title, and drives strategy through execution. You will operate as a critical member of a&nbsp;small, senior team, expected to deliver outsized impact without the infrastructure of a large organization. This role is best suited for individuals who have succeeded in complex dermatology markets and are motivated to assess issues, identify feasible solutions, make decisions, and operate with efficiency. Key Responsibilities: Strategic Leadership in a Lean Environment Partner directly with the SVP of Market Access to shape and refine U.S. access strategy. Own and drive high-priority components of pricing, payer positioning, and access execution—personally and with limited support. Challenge conventional approaches and bring forward differentiated strategies grounded in real-world payer behavior. Payer Strategy &amp; Market Impact Lead core elements of U.S. payer strategy, including positioning, coverage objectives, and contracting approach in highly managed, rebate-driven markets. Anticipate aggressive payer tactics (step edits, exclusions, reauthorization criteria) and design pragmatic, executable solutions for a small biotech. Engage directly with payer stakeholders and translate insights into actionable strategy. Value Story &amp; Evidence Translation Anticipate the future and develop clear, compelling payer value narratives that differentiate in crowded dermatology markets. Create compelling and workable outcomes contracting options that augment brand position. Translate clinical and economic evidence into practical tools that drive coverage decisions. Partner closely with HEOR and medical to ensure evidence generation is focused, efficient, and directly tied to access impact. Launch Execution &amp; Access Readiness Drive critical components of launch readiness, including payer engagement, distribution strategy input, and patient access solutions. Build—not just direct—key deliverables such as payer materials, access assumptions, and strategy frameworks. Partner with Insights and Analytics to create actionable dashboards for field team deployment. Competitive Edge &amp; Market Awareness Bring urgency and accountability to cross-functional teams. Apply deep understanding of dermatology and immunology market dynamics to anticipate competitor and payer behavior. Recognize patterns from prior market experience and adapt quickly to changing conditions. Continuously refine strategy based on real-time insights. Qualifications 10+ years of U.S. market access experience within biopharma, including an experience in a small company. Proven success driving meaningful components of access strategy in&nbsp;lean or resource-constrained environments. Comfortable navigating ambiguity and making decisions with imperfect information. Dermatology experience strongly preferred; immunology experience required. Experience in highly competitive, rebate-driven therapeutic categories required. Launch experience strongly preferred. Experience operating in small, agile organizations with limited infrastructure. Strong cross-functional leadership skills, with the ability to influence without authority. Agile, solutions-oriented leader with a strong bias for action. Bachelor’s degree required; advanced degree (MBA, PharmD, PhD, MPH) preferred. The salary range for this position is $270,000 USD to $320,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. &nbsp;&nbsp; &nbsp; This position is based in South San Francisco. Local candidates (onsite Tues-Thurs) are preferred. Will consider excellent candidates&nbsp;nation-wide if they are willing to travel regularly to South San Francisco. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents 401k match Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO&nbsp; Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way. &nbsp; &nbsp;

Senior Director, Market Access

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.&nbsp;Alumis is seeking a highly strategic and execution-oriented Senior Director, Trade Operations to lead the vision, design, and implementation of U.S. trade and distribution models across its dermatology and immunology portfolio. This individual will play a critical leadership role in shaping how products reach patients and providers through agile, efficient, and scalable access pathways. Reporting to the SVP, Market Access, this role will operate as a core member of a lean, high-impact commercialization team. The ideal candidate thrives in a nimble environment, brings a pragmatic and innovative mindset, and is comfortable building strategy from the ground up while remaining deeply involved in execution. Key Responsibilities: Trade &amp; Distribution Strategy Development Lead the design and execution of U.S. trade and distribution strategies, with a focus on specialty pharmacy and specialty distribution channels. Develop nimble, fit-for-purpose distribution models tailored to dermatology and immunology markets, enabling rapid adaptation to evolving payer and patient dynamics. Define channel strategy, including specialty pharmacy network design, limited distribution approaches, and wholesaler partnerships where appropriate. Partner with the SVP of Market Access and other commercialization leaders at Alumis to assess and implement new concepts for channel strategy. Strategic Execution &amp; Launch Readiness Translate strategy into actionable plans, including partner selection, contracting, and operational implementation. Build and implement scalable distribution frameworks to support pre-launch, launch, and ongoing optimization. Proactively identify and mitigate channel risks while maintaining flexibility to adjust strategy as market conditions evolve. Cross-Functional Leadership Partner closely with Market Access, Patient Services, Finance, Legal, Compliance, and Supply Chain to ensure coordinated and efficient execution. Act as the internal expert on trade and distribution, contributing to broader commercialization and access strategy. Collaborate within a small team of senior commercialization professionals, operating with shared accountability and a hands-on approach. External Partner Management Evaluate, select, and manage specialty pharmacies, specialty distributors, and third-party logistics providers. Lead distribution-related negotiations in partnership with Legal and Finance. Establish clear performance expectations and governance to ensure accountability and high-quality execution from partners. Market Insights &amp; Optimization Monitor industry trends and competitive distribution strategies within dermatology and immunology. Continuously refine channel strategy based on payer behavior, patient journey insights, and provider needs. Leverage data and analytics to inform decisions and drive ongoing optimization. Qualifications 10+ years of experience in biopharmaceutical commercialization, with deep expertise in trade, distribution, and channel strategy. Experience operating in small, agile organizations with limited infrastructure. Comfortable navigating ambiguity and making decisions with imperfect information. Strong understanding of dermatology and/or immunology markets preferred. Launch experience is strongly preferred. Proven experience designing and implementing specialty distribution models in the U.S. Strong cross-functional leadership skills, with the ability to influence without authority. Agile, solutions-oriented leader with a strong bias for action. Hands-on operator who leads by doing, not delegating. Bachelor’s degree required; advanced degree (MBA, PharmD, or similar) preferred. The salary range for this position is $270,000 USD to $320,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. &nbsp;&nbsp; This position is based in South San Francisco. Local candidates (onsite Tues-Thurs) are preferred. Will consider excellent candidates&nbsp;nation-wide if they are willing to travel regularly to South San Francisco. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. &nbsp; Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents 401k match Free access to Genentech Bus &amp; Ferry Share program $100 monthly cell phone stipend Unlimited PTO&nbsp; Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to&nbsp;elevate,&nbsp;challenge&nbsp;and&nbsp;nurture&nbsp;one another along the way. &nbsp; &nbsp; &nbsp; &nbsp;

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