Prime Medicine is a biotechnology company focused on developing innovative RNA-based therapeutics to treat genetic diseases. The company's cutting-edge research and technology aim to revolutionize the field of medicine by providing personalized treatments for patients with rare and common genetic disorders. With a dedicated team of scientists and experts, Prime Medicine is committed to advancing the future of healthcare through its groundbreaking approach to gene therapy.

prime-medicine

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.&nbsp; (Fall 2025 Cycle: July-Dec 2026) Co-Op Assignment Overview Prime Medicine is seeking a co-op for the Fall 2026 semester with experience and/or knowledge in natural science such as Biology, Chemistry or other biotech-related disciplines to join the Regulatory Affairs team. The Prime Medicine Regulatory Affairs team is a tight-knit, closely collaborative, highly creative group working to make the promise of Prime Editing a reality for patients with severe genetic diseases. The qualified candidate will be highly motivated, analytical and collegial. The candidate will support the Regulatory Affairs team in ensuring compliance with relevant regulations and guidelines relevant to the company's gene editing pipeline programs for patients with genetic diseases. You will assist in researching, interpreting, and implementing regulatory requirements, as well as providing administrative support for regulatory submissions and documentation. &nbsp; Primary Responsibilities: · Conduct research on regulatory requirements pertinent to the company's product pipeline. Stay updated on changes in regulations and guidelines affecting the industry. &nbsp; · Assist in maintaining regulatory documentation, spreadsheets, and trackers related to the compilation of required inputs for regulatory submissions. Ensure all documents and trackers are organized and up to date. &nbsp; · Support the preparation, compilation, and submission of regulatory documents to FDA and ex-US regulatory agencies. This may include applications for regulatory agency meetings, drug designations, and/or investigational new drug applications. &nbsp; · Assist in monitoring compliance of clinical-stage development programs with regulatory requirements and adherence to regulations. &nbsp; · Cross-functional collaboration with other departments, such as R&amp;D, preclinical, and clinical teams to gather information and help ensure regulatory compliance in product development, testing, and regulatory submission packages. &nbsp; · Assist in preparing regulatory reports and responses to regulatory inquiries. &nbsp; · Participate in training sessions and educational programs to enhance understanding of regulatory requirements and processes. &nbsp; · Undertake additional ad-hoc tasks and projects as assigned by the Regulatory Affairs team to support departmental objectives and business needs. &nbsp; Qualifications: · Currently enrolled in a Bachelor's or Master's degree program in a relevant field such as Regulatory Affairs, Life Sciences, Pharmacy, Biology, or a related discipline. · Strong attention to detail and organizational skills. · Excellent analytical, written and verbal communication skills. · Ability to work independently and collaboratively in a team environment. · Proficiency in Microsoft Office suite (Word, Excel, PowerPoint). &nbsp; Preferred Qualifications (but not required): · Prior experience, course work, and/or certification in regulatory affairs. · Familiarity with medical terminology. · Basic understanding of cellular and molecular biology underlying gene therapy. · Familiarity with document management systems and spreadsheets (Smartsheet, Excel, etc.). &nbsp; U.S. Pay Range $23-$33 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Co-op: Regulatory Affairs

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Job Title Director, Patient Advocacy &amp; Medical Affairs Reports To VP of Clinical Development Position Summary Prime Medicine is seeking an Associate Director or Director, Patient Advocacy &amp; Medical Affairs to lead patient-focused engagement across our rare disease gene-editing programs. This role is central to ensuring that the patient voice meaningfully informs development strategy, clinical trial design, and external engagement, while also supporting Medical Affairs activities with credible, patient-grounded insights. The successful candidate will build trusted relationships with patient communities, advocacy organizations, caregivers, and clinicians, and will work cross-functionally with Clinical Development, Medical Affairs, Regulatory, and Communications teams. This is a highly collaborative role for a leader who combines deep empathy and credibility with patients and a strong understanding of medical, scientific, and regulatory contexts. Key Responsibilities Patient Advocacy Leadership Serve as the primary internal advocate for patients and caregivers across rare disease programs. Build and maintain long-term, trust-based relationships with: Patient advocacy organizations Patient leaders and caregivers Community groups and foundations Ensure patient perspectives are integrated into: Clinical trial design and execution Endpoint selection and feasibility considerations Study materials and participant experience Lead patient advisory boards, listening sessions, and community engagements in a compliant and transparent manner, including oversight of sponsorship activities and events as well as inquiry tracking. Partner with cross-functional teams to incorporate patient insights into development decisions. Medical Affairs Partnership &amp; Support Collaborate closely with internal teams to: Support external scientific engagement with healthcare professionals and key opinion leaders Ensure patient-focused insights inform medical strategy and external education Contribute to the development and review of: Medical and scientific communication materials Patient-facing educational resources Advocacy-appropriate disease and treatment education content Support congress planning, advisory boards and patient panels, and non-promotional medical education activities with a patient-centered lens. Clinical Development &amp; Cross-Functional Collaboration Partner with Clinical Development and Clinical Operations to: Provide patient-centric input on protocol design, inclusion/exclusion criteria, and visit burden Improve trial awareness, access, and participant experience Support regulatory interactions and briefing materials by articulating patient needs and unmet burden. Collaborate with Regulatory and Legal teams to ensure advocacy activities are compliant and aligned with company values. Strategy, Insights &amp; Impact Monitor and synthesize patient community insights, unmet needs, and emerging trends across relevant rare diseases. Translate patient insights into actionable recommendations for leadership and program teams. Help shape long-term patient engagement strategy as programs advance through development. Represent the company externally as a credible, compassionate, and scientifically grounded partner to the patient community. Qualifications Required Bachelor’s degree required; advanced degree (Master’s, PhD, PharmD, MD, MPH) preferred. 15+ years of experience in patient advocacy, medical affairs, rare disease engagement, or related roles within biotech, pharma, federal or nonprofit settings. Demonstrated experience working directly with patient advocacy organizations and patient communities. Strong understanding of clinical development and medical affairs in rare diseases. Excellent communication skills, with the ability to translate complex science into patient-appropriate language. Proven ability to collaborate cross-functionally in a fast-paced, mission-driven environment. Preferred Experience in gene therapy, gene editing, or other advanced modalities. Industry experience supporting early-stage clinical programs. Familiarity with regulatory and compliance considerations for patient engagement. Background in rare genetic diseases. The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$213,000&mdash;$261,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Director, Patient Advocacy & Medical Affairs

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview We are seeking a motivated and skilled Senior Scientist to join the Nonclinical Development group, contributing to the DMPK function in support of exploratory and IND-enabling programs across Prime Medicine’s pipeline. Reporting to the Associate Director, DMPK/Bioanalytical Sciences, this individual will independently analyze and interpret datasets from in vivo studies, contribute to nonclinical regulatory documents, and work cross-functionally with pharmacology, translational biology and external CROs, to ensure high-quality DMPK data packages are delivered to support program timelines. The ideal candidate has a strong foundation in in vivo pharmacokinetics for RNA therapeutics and/or LNP-based delivery systems, thrives in a fast-paced and matrixed organization, and possesses the flexibility and positive attitude needed to make meaningful contributions to the Nonclinical Development team. Primary Responsibilities Analyze and interpret PK study data from exploratory and IND-enabling in vivo Perform non-compartmental analysis (NCA) using Phoenix WinNonlin to derive key PK parameters (Cmax, AUC, T½, Vd, CL). Leverage expertise in DMPK to provide recommendations for in vivo study designs in collaboration with pharmacology and key stakeholders. Perform bioanalytical assay development (30%) and collaborate with bioanalytical scientists to trouble-shoot challenges during method development to ensure quantitative methods for key analytes (LNP lipid components, mRNA, pegRNA, PD biomarkers) meet regulatory expectations and data quality standards.. Contribute to nonclinical regulatory documents including pharmacokinetics summaries and nonclinical study reports under the guidance of senior stakeholders in Nonclinical Development. Maintain thorough records in the electronic laboratory notebook (ELN); prepare clear data summaries, presentations, and technical memos for program team and governance meetings. &nbsp; Qualifications Minimum Qualifications D. in pharmacokinetics, pharmaceutical sciences, pharmacology, biochemistry, or a related discipline. 6+ years of cumulative experience. Industry experience (biotech or pharmaceutical) with direct responsibility for in vivo DMPK study design, execution, and interpretation is required; postdoctoral training in a DMPK or translational pharmacology setting is strongly preferred Demonstrated experience with in vivo PK studies in preclinical models and proficiency in NCA using Phoenix WinNonlin or equivalent software. Familiarity with regulatory expectations for nonclinical DMPK assessments and bioanalytical assay development. Demonstrated ability to coordinate with external CROs, including scientific guidance, protocol development, and data review.. Strong written and verbal communication skills; ability to present complex DMPK data clearly to multidisciplinary audiences. Highly self-motivated, collaborative, and organized, with the ability to manage multiple priorities independently in a fast-paced matrix environment. &nbsp; Preferred Qualifications Familiarity with PK/PD modeling concepts; experience with Phoenix WinNonlin modeling modules a plus. Experience with LNP-based delivery systems and/or RNA therapeutics (mRNA, siRNA, ASO, sgRNA or related modalities). Experience with exploratory DMPK studies, evaluating new delivery vehicles and evaluation of biodistribution using in vivo Familiarity with bioanalytical platforms supporting DMPK studies, including LC-MS/MS, RT-qPCR/ddPCR, ELISA/MSD. Ability and excitement to contribute to the development and success of the Nonclinical Development team. The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$145,000&mdash;$177,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Senior Scientist, Drug Metabolism & Pharmacokinetics (DMPK)

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview We are seeking an enthusiastic, self-motivated Senior Scientist to join the Nonclinical Development group, supporting the nonclinical safety assessment function for IND-enabling programs across Prime Medicine’s pipeline. Reporting to the Associate Director, Safety Assessment, the successful candidate will support the design, execution, and interpretation of nonclinical safety studies conducted both in-house and at CROs, with an initial focus on liver-targeted therapeutics. This role requires hands-on involvement in assay execution and troubleshooting, as well as active participation in study oversight of work being done at CRO and data analysis. This role requires collaboration within cross-functional teams. The ideal candidate will hold a Ph.D. in toxicology or a related field with 6+ years of pharma/biotech experience in nonclinical safety assessment, or an M.S. in toxicology or a related field with 10+ years of experience in nonclinical safety assessment, the ability to work independently, provide domain expertise and leadership, as well as cross-functionally in a fast-paced, matrixed environment with a positive, flexible attitude. &nbsp;&nbsp; Primary Responsibilities Contribute to nonclinical safety activities as part of cross-functional Discovery and Development project teams, supporting program progression through IND-enabling stages. Design, execute, and troubleshoot nonclinical safety studies, including hands-on laboratory work (~30%) to support assay development, data generation, and issue resolution. Support the execution and oversight of nonclinical safety studies (GLP and non-GLP) at CROs, including active involvement in troubleshooting assay and study-related challenges. Analyze and interpret study data with guidance and contribute to the preparation of study reports and supporting documents for regulatory submissions. Collaborate with Pharmacology, DMPK, and other functions to support exploratory studies (e.g., exploratory toxicology, DMPK, biodistribution, and delivery platform evaluation). Contribute to evaluation of new delivery approaches, Lipid and RNA components, and emerging targets to support pipeline expansion. Assist in identifying potential safety findings and contribute to discussions on data interpretation and next steps. Ensure studies and internal activities are conducted in compliance with regulatory guidelines and internal standards. Preferred Qualifications Ph.D. in toxicology or a related discipline with 6+ years of biopharmaceutical industry experience, or M.S. in toxicology or a related field with 10+ years of relevant biopharmaceutical industry experience supporting drug development in nonclinical safety/toxicology. Experience in large molecule therapeutic development, along with a background in immunology, is desirable. Understanding of toxicology principles, nonclinical safety evaluation, and the drug development process, with some experience interpreting toxicology data and contributing to technical and scientific reports. Demonstrates strong scientific judgment and leadership with the ability to evaluate information, identify potential issues, and propose practical solutions with guidance as needed. Highly organized and detail-oriented with strong attention to accuracy and quality. Strong communication and collaboration skills, with the ability to work effectively across multidisciplinary teams and with external partners. Experience supporting nonclinical studies at CROs is preferred but not required. The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$145,000&mdash;$177,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Senior Scientist, Safety Assessment

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA.&nbsp; A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.&nbsp; We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients.&nbsp; Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives. Position Overview Prime Medicine is seeking a talented and motivated Sr. Manager to join the Analytical Development &amp; QC team within Technology, Development &amp; Operations. This role will focus on Quality Control (QC) related activities for all programs, including management and technical oversight of tech transfer, qualification/validation and release and stability testing carried out at both CDMOs, CTLs and internally at Prime for our prime editing ex vivo cell therapy and in vivo LNP-based drug products. The successful candidate will have deep understanding of method lifecycle management, including method optimization, qualification, validation/verification, transfer, and implementation in a cGMP environment, as well as previous hands-on experience in at least some aspects of the above. This is a role requiring strong cross-functional collaboration with Analytical Development, Quality, Process Development, Formulation, Informatics, and external partners (CTLs/CDMOs).&nbsp; The ideal candidate thrives in a matrixed, fast-paced environment, works effectively with limited supervision, and demonstrates strong technical ownership and execution. Key Responsibilities Design or review analytical procedures and protocols supporting method lifecycle activities, including optimization, qualification, validation, transfer, verification, performance monitoring, bridging, and comparability studies Manage and conduct select release, stability, and in-process testing for drug substances, drug products, and gene-editing components, and carry out data analysis and trending Support and/or manage analytical method transfer to CTLs/CDMOs, providing oversight, troubleshooting, and ensuring technical and timeline objectives are met Manage GMP sample inventory and chain-of-custody documentation Lead, manage and maintain well-designed stability programs and reference standard programs Author and review protocols, reports, SOPs, and analytical sections of regulatory submissions Familiarity with and ability to learn and use new tools for productivity, project management, documentation, tracking scheduling, and data management. Support IQ/OQ/PQ of QC equipment and ensure compliance with 21 CFR Part 11 Maintain GxP-compliant electronic documentation and thorough laboratory records Collaborate with Quality to ensure data integrity, regulatory compliance, and audit readiness Lead or support investigations, deviations, and root-cause analyses Present data and findings to cross-functional teams Prepare technical reports and documents for global regulatory submissions Qualifications Education &amp; Experience BS/MS/PhD in Biochemistry, Molecular biology, Chemistry, Bioengineering, or a related discipline Industry experience: BS: 10+ years MS: 8+ years PhD: 3+ years Technical Expertise Experience with analytical method optimization, tech-transfer, qualification, validation, and verification used for critical components, drug substance and drug product release and stability testing Hands-on experience with analytical methodologies such as: Chromatography-based assays Absorbance-based assays Cell-based assays Compendial assays Molecular-based assays Flow cytometry assays Familiarity with ICH and FDA guidelines for CMC development during clinical stage is required Experience in advanced cell and gene-editing therapeutics development is not mandatory, but highly desirable Experience working with CMOs/CDMOs is required Experience with stability and/or reference standard programs is a plus Knowledge of assays, instrumentation, and facility qualification/validation requirements is desirable Familiarity with regulatory writing Personal Attributes Highly self-motivated with strong project ownership Strong collaborator with internal cross-functional and external partners Adaptable in a dynamic, fast-paced environment Detail-oriented with strong troubleshooting and problem-solving skills Excellent written and verbal communication skills Strong abilities to lead and facilitate technical meetings with CDMO and CTL SMEs Work with purpose and drive meaningful results Ability to innovate and challenge industry status quo Ability to travel for up to 5 - 10% of the time Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability, protected veteran status, or any other characteristic protected by law.The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$144,000&mdash;$176,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Sr. Manager, QC

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview: We are seeking an experienced and motivated Scientist II to join the Cell therapy team within the Process Development department to execute on supporting BLA activities associated with PM359 ex vivo cell therapy program. This role is central to overseeing process validation and clinical manufacturing oversight at our CDMO partner and to provide technical documentation needed for regulatory submissions. This is an exciting opportunity to work at the intersection of cell biology, cell processing, bioengineering, and manufacturing to bring a breakthrough genetic medicine to patients in need and to gain experience with product licensure.&nbsp; This is a hands-on, technical role where the successful candidate will be involved in multiple technical and external manufacturing activities, so excellent organizational abilities, communications and collaboration are critical. The ideal candidate thrives when working in a fast-paced environment, working with purpose, and making an impact for patients. &nbsp;Primary Responsibilities: Apply knowledge in ex vivo cell therapy manufacturing unit operations (i.e., cell isolation, electroporation, culture, formulation, and cryopreservation) to prepare technical reports and documents for BLA. Use knowledge of CPPs, PARs/NORs and QbD applied to process validation. Collaborate with Analytical Development and Quality to document the process control strategy. Serve as Subject Matter Expert (SME) to provide on-site support at the CDMO, oversee process execution, contribute to knowledge transfer and operator training, review batch records, investigate and close process deviations, and analyze manufacturing trends to recommend improvements. Represent Cell Therapy MSAT on cross-functional team meetings; provide technical assessments and risk mitigation strategies.&nbsp; Broaden experience and expertise by supporting other platform technologies associated with PM359 and then provide expertise to other pipeline programs.&nbsp; &nbsp; Qualifications PhD in Bioengineering, Chemical Engineering, Immunology, or related life science field with 3+ years of industry experience; or M.S/BS with 8+/10+ years of directly applicable full-time work experience. Deep hands-on experience in cell therapy manufacturing including cell isolation, gene editing, electroporation, cell culture, formulation, and cryopreservation Experience with automated cell therapy unit operations required (e.g., Rotea, LOVO, CliniMACS); experience with cell therapy analytical methods preferred Proven experience overseeing or working within cGMP manufacturing at a CDMO or internal GMP facility, including experience being the Person-In-Plant during campaigns, batch record creation and review. Proficiency with DoE and statistical methods for process characterization; ability to link process parameters to product quality outcomes Excellent written and verbal communication skills; ability to clearly present technical data to cross-functional audiences. Highly self-motivated, detail-oriented, and able to operate independently with strong ownership mindset. Comfortable in a fast-paced, matrixed biotech environment with evolving priorities. Familiarity with common statistical analysis tools (e.g., JMP, Minitab), project management tools (e.g., Smartsheet), and productivity tools including generative AI (e.g., Claude, ChatGPT). Ability to travel to manufacturing site up to 20% of the time as needed. Preferred Qualifications Experience with late-stage HSC or T cell therapy process development, including PPQ execution and/or BLA CMC authorship; rare-disease program experience is considered a plus Prior experience as a Sponsor-side person-in-plant representative or as a cell therapy CDMO technical representative working with Sponsors. Familiarity with regulatory submission writing and review. The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$131,000&mdash;$161,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Scientist II -  Cell Process Development

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.&nbsp; Position Overview: Join a collaborative, agile and dynamic Clinical Development Operations (CDO) team by leading and contributing to transformative clinical programs for patients in rare diseases and beyond. In this position, you will be hands-on in day-to-day study execution, working closely with internal study team members, clinical sites, and external CROs and vendors. This position is ideal for someone who thrives in a fast-paced, evolving environment, is comfortable wearing multiple hats, and is eager to learn more about clinical trial management and execution. This is a hybrid role requiring a combination of in-office presence (Watertown, MA) and remote work, with expectations aligned to team and business needs. &nbsp; Key Responsibilities: · Support the execution of clinical trials from startup through closeout, ensuring adherence to protocol, timelines, and quality standards · Assist with site startup activities, including regulatory document collection, IRB/EC submissions, and site readiness/activation · Support development of study and site-facing materials (e.g., ICFs, recruitment materials, study manuals, CCGs, study tools) and coordinate cross-functional review and approval · Prepare and maintain meeting minutes, action items, and follow-ups for key study team meetings · Maintain study documentation (e.g., sponsor TMF oversight and ISF support) to ensure completeness, quality, and inspection readiness · Oversee CRO/vendor TMF activities, ensuring alignment with sponsor expectations, TMF plans, and filing timelines · Track study progress, enrollment, IRB/EC submissions and queries, and key operational metrics; proactively identify and escalate risks to timelines or deliverables · Serve as a primary point of contact for CRAs and sites to address day-to-day operational questions and issues · Track and monitor key subject visits and study milestones to ensure protocol compliance and data integrity · Support inspection readiness activities, including TMF reviews, audit support, and resolution of findings · Support clinical sample management activities, including coordination of central labs, sample logistics, tracking, and issue resolution · Review clinical data, monitoring reports, and protocol deviations to ensure quality, compliance, and timely issue resolution · Contribute to SOP development, process improvements, and operational best practices within a growing organization &nbsp; Qualifications: · BS/BA/RN Degree in science or a health-related field is preferred · Minimum 2–4 years of clinical research experience; sponsor experience is strongly preferred. · Familiarity with clinical trial operations, ICH-GCP, and regulatory requirements · Experience and understanding of EDC systems, TMF systems, and clinical trial documentation · Familiarity with clinical data review and data management processes, including Data Monitoring Committees · Highly organized with strong attention to detail · Ability to manage multiple priorities with a sense of urgency in a fast-paced environment · Strong communication and relationship-building skills · Resourceful, proactive problem-solver with a “do-what-it-takes” mindset · Comfortable operating in a dynamic environment with evolving processes and priorities · Self-motivated, collaborative, and able to work both independently and cross-functionally · Positive, team-oriented attitude with a passion for advancing innovative therapies for patients · Excitement to contribute to Prime Medicine’s culture! &nbsp; Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability, protected veteran status, or any other characteristic protected by law. &nbsp;The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$117,000&mdash;$143,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Sr. Clinical Research Coordinator, Clinical Operations

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Summary The Staff Accountant will play a key role in the accounting and financial activities for Prime Medicine.&nbsp; In this crucial role, the Staff Accountant will have exposure to a wide range of business and operational initiatives, accounting and financial reporting activities and ad hoc projects. This role is focused on monthly and quarterly close financial procedures and supports the Procure-to-Pay functions.&nbsp; The candidate will join an evolving finance and accounting team recognized as valued business partners. This position offers exposure to many levels of the organization, providing outstanding opportunities to influence the direction of the business and to grow your career. Position will report directly to Associate Director of Procurement.&nbsp; &nbsp; Key Responsibilities Execute month-end, quarter-end, and year-end close activities in a timely and accurate manner, including preparation and posting of journal entries, account reconciliations, roll forwards and variance analyses Provide internal customer service support for the Procure-to-Pay (P2P) processes and day-to-day activities, ensuring users are properly trained and transactions are recorded accurately Maintain Vendor Master File and act as the primary contact for vendor inquiries regarding payment status and statement reconciliation Lead efforts around accounts payable efficiencies, including driving automation and other process enhancements Manage weekly cash disbursement processes, coordinate payment approvals and payment timing Oversee and manage Concur for employee expense reports from review to reimbursement, ensuring compliance with company policies Manage fixed assets and depreciation ensuring compliance with accounting standards and company policies Support external and internal audits by preparing schedules, reconciliations, and documentation Ensure business transactions continue to be in accordance with generally accepted accounting principles, policies, and SOX controls Assist with special projects and ad-hoc analysis across accounting functions as assigned &nbsp; Education &amp; Experience Bachelor’s degree in finance or accounting (preferred), with 2-3 years of progressive accounting experience with at least 2 years in public accounting or a high-growth tech/life sciences company Strong understanding of U.S. GAAP and willingness to deepen technical accounting knowledge Proficiency in MS Office (especially Excel) and experience with accounting/ERP software &nbsp; Required Skills &amp; Competencies Demonstrated analytical skills to solve complex problems and address a variety of variables in situations with limited standardization Strong organizational skills to effectively balance priorities, handle workload, and complete projects on time Highly organized and diligent, with time management abilities Strong interpersonal skills for effectively communicating with internal &amp; external stakeholders of all levels. Ability to work independently across multiple financial systems and troubleshoot/resolve issues as needed. Self-motivated and capable of working independently Hybrid work position with some in-person attendance required (Cambridge, MA) The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$86,000&mdash;$113,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Staff Accountant

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Role Summary Prime Medicine is seeking an AI &amp; Informatics Engineer to join our AI Foundry and support our pipeline delivery.&nbsp; This includes designing and building the data and computational infrastructure that powers our prime editing programs. This role spans laboratory informatics, NGS pipeline development, and AI-enabled tooling, giving the right candidate a direct line from the work they do to the therapies we develop. You will partner closely with research scientists, computational biologists and technical development professionals, turning raw data into reliable scientific insights, and building automation and AI capabilities that let teams work faster and smarter. Our ideal candidate brings strong software engineering fundamentals, hands-on NGS pipeline experience, a practical understanding of modern AI frameworks, and the biological intuition to translate scientific needs into working systems. Equally welcome are candidates who entered this space from the life sciences side and have built serious software skills along the way. This is an action packed and dynamic role where the successful candidate will be involved in multiple programs and activities, so excellent organizational abilities, communications and strong collaboration are critical. The ideal candidate thrives when working in a fast-paced environment, working with purpose, and making an impact for patients. Key Responsibilities NGS Pipelines and Data Infrastructure Design, develop, and maintain scalable bioinformatics pipelines for NGS data analysis, including amplicon sequencing for on-target editing quantification, using Nextflow and Docker to ensure reproducibility. Build and maintain data infrastructure connecting NGS instruments, electronic laboratory notebooks (e.g., Benchling), data repositories, and AWS cloud compute, including automated data ingestion, scalable storage, and provenance tracking. Build APIs, MCPs, dashboards, and other internal tools that expose genomic data and analytical capabilities to scientific and cross-functional teams. Laboratory Informatics Support implementation and ongoing development of laboratory informatics systems, including data ingestion from key instruments and integration with laboratory data platforms such as Benchling. Support vendor relationships and delivery outcomes for external collaborators, driving requirements, managing implementations, and ensuring high-quality delivery. AI-Powered Tools and Automation Build AI-powered and agentic capabilities that automate routine work, support scientific reasoning, and improve how data and knowledge flow across the organization. Develop reusable platform components for retrieval, orchestration, and model interaction, with human-in-the-loop workflows that make AI systems transparent and practical for scientific users. Identify and address automation opportunities and scalability bottlenecks across research and operational workflows. Engineering Practices Write production-grade code using Git-based workflows, peer review, testing, CI/CD, and documentation best practices; convert research prototypes into robust, maintainable software. Build integrations between internal tooling and third-party platforms to support evolving scientific and operational needs. Participate in cross-functional projects spanning lab operations, software engineering, and bioinformatics; recommend best practices, system architectures, and design patterns. Perform code reviews and contribute to documentation of engineering and cross-functional practices. Qualifications Required BS with 5+ years or MS with 3+ years of industry experience in Engineering, Bioinformatics, Data Sciences, or a related field. Candidates with biotech or life sciences with substantial software experience are strongly preferred. Strong Python development; proficiency with Nextflow (or comparable workflow tools), Docker, AWS, Linux/Unix, and Git. Experience developing and deploying bioinformatic data infrastructure, particularly NGS analysis pipelines. Experience implementing or integrating laboratory informatics systems, preferably including Benchling. Experience developing and maintaining production-grade APIs and SDKs, and rolling out software tooling across an organization. Familiarity with LLM frameworks and practical judgment about where agentic approaches add genuine value. Track record of shipping software that scientific or technical users adopt and rely on. Preferred Experience building and deploying AI-powered tools or agentic systems in production or research settings. Familiarity with gene editing applications (CRISPR, base editing, or prime editing), including amplicon-seq workflows and tools such as CRISPResso. Familiarity with relational databases and data visualization tools (e.g., Plotly Dash, Streamlit, Spotfire). Experience in a GxP or regulated software environment (21 CFR Part 11, GAMP 5). Experience owning vendor relationships and delivery outcomes for external collaborators in laboratory informatics contexts. Why This Role Prime editing is a precise technology, and that precision depends on strong informatics, software, and scientific infrastructure. If you believe that better systems, better automation, and better access to data can translate into safer and more effective therapies, this is the right environment. You will build tools that directly shape how Prime generates, analyzes, and acts on scientific data, while helping lay the foundation for programs to come.The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$134,000&mdash;$163,000 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

AI & Informatics Engineer

Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. &nbsp; Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology &amp; oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.Position Overview: &nbsp; Prime Medicine is seeking a skilled legal intern to join our legal team and play a key role in supporting the company’s mission to develop next-generation gene editing therapies. This role will focus on contract review, legal research, and compliance, while gaining exposure to business law and general legal counsel. Responsibilities include drafting, analyzing risk, and supporting attorneys, offering hands-on experience in corporate, intellectual property, and employment law. This position requires close collaboration with internal stakeholders and external partners to ensure effective legal support that advances Prime Medicine’s strategic objectives. Key Responsibilities: Assist in reviewing, drafting, and negotiating commercial agreements, sales, and vendor contracts. Conduct legal research, draft legal memoranda, and prepare corporate documents. Support the legal team in ensuring compliance with regulations and developing internal company policies. Organize legal files, assist with corporate record-keeping, and help with intellectual property matters. Participate in meetings with internal business units, outside counsel, and stakeholders. Qualifications: Current enrollment in an accredited law school (JD candidate). Strong legal research, writing, and communication skills. High level of professionalism, discretion, and ability to handle confidential information. Basic understanding of corporate law, commercial transactions, or compliance. Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability, protected veteran status, or any other characteristic protected by law.The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.U.S. Pay Range$26&mdash;$26 USDPrime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

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